Aprepitant Drug in Ternary Pharmaceutical Solid Dispersions with Soluplus® and Poloxamer 188 Prepared by Melt Mixing
نویسندگان
چکیده
منابع مشابه
Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®.
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble aprepitant by preparation of solid dispersions. The solid dispersions were characterized by dissolution, FTIR, XRPD, DSC, SEM...
متن کاملPreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...
متن کاملHot melt extruded Aprepitant-Soluplus solid dispersion: preformulation considerations, stability and in vitro study.
CONTEXT Solubility limitation of BCS class II drugs pose challenges to in vitro release. OBJECTIVE To investigate the miscibility of Aprepitant (APR) and Soluplus(®) (SOL) for hot melt extrusion (HME) viability and improved in vitro release of APR. METHODS Solubility parameters of APR and SOL from group contribution methods were evaluated. Heat-cool-heat differential scanning calorimetry (D...
متن کاملPreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...
متن کاملpreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and pvp-k30 as carriers
objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...
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ژورنال
عنوان ژورنال: Sci
سال: 2019
ISSN: 2413-4155
DOI: 10.3390/sci1010029